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ammonia is the most toxic and will cause death in very low concentrations. Problems associated with non-lethal elevated levels of ammonia include gill disease, dropsy and finrot. The higher the pH and the temperature, and the lower the salinity or hardness, the greater the ratio of free ammonia to the ionized form. Thus, the higher the pH and or the temperature, the more toxic the ammonia. Test kits measure the total ammonia (free plus ionized). With a properly functioning biological filter, the ammonia level is usually zero in the pond and should be under .1ppm (mg/l). Nitrosomonas bacteria in the filter oxidize ammonia into nitrite, our next compound. If the level of ammonia is elevated, you should immediately add ammonia remover such as Tetra Aquasafe, Kordon AmQuel or make partial water changes. You should also add nitrifying bacteria to your filter and stop feeding your fish until the situation is corrected.However, aspirin and NSAIDS do not directly affect the other pain chemicals and do not affect the pain nerve, the C fiber.
Narcotics, such as Darvon or codeine, have no known effect on either the "pain" bio-chemicals or the pain nerves. Acetaminophen (Tylenol) also has no significant effect on these at usual doses. And in fact, the way acetaminophen works is not actually known.
But we also know we can interrupt the pain impulse away from the injury site, at the spinal cord. If our pain killer could also decrease the release of (or deplete the C fiber of) Substance P, the pain impulse would be blocked at the spinal cord level. Aspirin and NSAIDS have no known effect at this site. Narcotics and tricyclic antidepressants, such as amitriptylene or Elavil, on the other hand, actually can block the release of Substance P and stop transmission at the spinal cord level, but once again have no value in decreasing the levels of the bio-chemicals of pain.
Saturday, October 13, 2007
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